Taking Fish Oil And Vitamin C Together

Taking Fish Oil And Vitamin C Together

Brief Summary:

Combining fish oil and vitamin C supplementation will provide a greater anti-inflammatory effect against developing exercise-induced bronchoconstriction (EIB) than either nutritional supplement alone.


Condition or disease Intervention/treatment Phase
Asthma Dietary Supplement: Fish Oil Dietary Supplement: Ascorbic Acid Dietary Supplement: Fish Oil Placebo Dietary Supplement: Ascorbic Acid Placebo Phase 1

Detailed Description:

The aim of this study is to extend previous findings that nutritional supplementation or dietary modification can ameliorate exercise-induced bronchoconstriction. It has been shown in separate studies that fish oil and ascorbic acid (vitamin C) individually protect against EIB by improving pulmonary function and reducing airway inflammation. The main aim of this study is to determine the comparative and additive effects of fish oil and ascorbic acid supplementation on EIB and airway inflammation in asthmatic individuals.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Comparative and Additive Effects of Fish Oil and Ascorbic Acid Supplementation on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma
Study Start Date : March 2010
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Active Fish Oil + Vitamin C Placebo

Fifteen subjects will take 10 active fish oil capsules per day and 2 vitamin C placebo capsules per day for 3 weeks.

Dietary Supplement: Fish Oil

10 fish oil (3.2g EPA + 2.0g DHA) capsules per day for 3 weeks


Dietary Supplement: Ascorbic Acid Placebo

2 placebo ascorbic acid (sucrose) capsules per day for 3 weeks

Other Name: Table Sugar


Experimental: Fish Oil Placebo + Active Vitamin C

Fifteen subjects will take 10 fish oil placebo capsules per day and 2 active vitamin C capsules per day for 3 weeks.

Dietary Supplement: Ascorbic Acid

2 pharmaceutical grade ascorbic acid (1500mg) capsules per day for 3 weeks

Other Name: Vitamin C


Dietary Supplement: Fish Oil Placebo

10 placebo fish oil (soy bean oil) capsules per day for 3 weeks

Other Name: Soy Bean Oil


Experimental: Active Fish Oil + Active Vitamin C

Following a 2-week washout period, all subjects from the other two arms (n=30) will take 10 active fish oil capsules per day and 2 active vitamin C capsules per day for 3 weeks.

Dietary Supplement: Fish Oil

10 fish oil (3.2g EPA + 2.0g DHA) capsules per day for 3 weeks


Dietary Supplement: Ascorbic Acid

2 pharmaceutical grade ascorbic acid (1500mg) capsules per day for 3 weeks

Other Name: Vitamin C





Primary Outcome Measures :

  1. Pulmonary Function [ Time Frame: 8 weeks ]

Secondary Outcome Measures :

  1. Exhaled nitric oxide to measure airway inflammation [ Time Frame: 8 weeks ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study: 18 Years to 40 Years   (Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria:

  • Diagnosis of asthma, based on medication use as well as history and symptoms as outlined in the NHLBI Guidelines for the Diagnosis and Management of Asthma
  • Diagnosis of EIB, based on ≥10% fall in post-challenge FEV1, a measure of lung function, after dry air eucapnic voluntary hyperventilation (EVH), a simulated exercise challenge
  • Not currently taking asthma maintenance medication or physician approval to discontinue current asthma medication for the duration of the study
  • Not currently taking any fish oil or ascorbic acid supplements above the level recommended for adequate intake (if currently taking supplements, can participate if the subject stops taking the supplements for 2 weeks before starting the study and throughout the study)
  • Agree to limit fish consumption to 1 fish meal per week throughout the study
  • Agree to avoid vitamin C-rich foods throughout the study

Exclusion Criteria:

  • Resting FEV1 (the amount of air blown out in the first second of a forced exhalation) <60% of predicted when off medication
  • Pregnancy
  • History of cardiovascular disease, including hyperlipidemia (high cholesterol) and hypertension (high blood pressure)
  • History of bleeding disorders or delayed clotting time
  • History of diabetes
  • History of seizures
  • Allergy to fish oil or ascorbic acid (vitamin C)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01057615


Locations

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United States, Indiana
Indiana University
Bloomington, Indiana, United States, 47405

Sponsors and Collaborators

Indiana University

Investigators

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Study Director: Timothy D Mickleborough, PhD Indiana University

Publications:


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Responsible Party: Timothy Mickleborough, PhD / Associate Professor, Indiana University
ClinicalTrials.gov Identifier: NCT01057615
Other Study ID Numbers: 0910000751
First Posted: January 27, 2010    Key Record Dates
Last Update Posted: January 31, 2011
Last Verified: January 2011

Keywords provided by Indiana University:

Asthma
Exercise-Induced Bronchoconstriction
Inflammation
Airway
Fish Oil
Ascorbic Acid

Additional relevant MeSH terms:

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Asthma
Inflammation
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases
Pathologic Processes
Ascorbic Acid
Vitamins
Micronutrients
Physiological Effects of Drugs
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents


Taking Fish Oil And Vitamin C Together

Source: https://clinicaltrials.gov/ct2/show/NCT01057615#:~:text=Combining%20fish%20oil%20and%20vitamin,than%20either%20nutritional%20supplement%20alone.

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